Publications of Tobias J. Erb

Yilmaz, S.; Kanis, B.; Hogers, R. A.H.; Benito-Vaquerizo, S.; Kahnt, J.; Glatter, T.; Dronsella, B.; Erb, T. J.; Suarez-Diez, M.; Claassens, N. J.: System-level characterization of engineered and evolved formatotrophic E. coli strains. Synthetic and Systems Biotechnology (2025)

Orsi, E.; Schulz-Mirbach, H.; Cotton, C. A. R.; Satanowski, A.; Petri, H. M.; Arnold, S. L.; Grabarczyk, N.; Verbakel, R.; Jensen, K. S.; Donati, S. et al.; Paczia, N.; Glatter, T.; Küffner, A. M.; Chotel, T.; Schillmüller, F.; De Maria, A.; He, H.; Lindner, S. N.; Noor, E.; Bar-Even, A.; Erb, T. J.; Nikel, P. I.: Computation-aided designs enable developing auxotrophic metabolic sensors for wide-range glyoxylate and glycolate detection. Nature Communications 16 (1), 2168 (2025)

Dronsella, B.; Orsi, E.; Schulz-Mirbach, H.; Benito-Vaquerizo, S.; Yilmaz, S.; Glatter, T.; Bar-Even, A.; Erb, T. J.; Claassens, N. J.: One-carbon fixation via the synthetic reductive glycine pathway exceeds yield of the Calvin cycle. Nature Microbiology (2025)

Schulz, L.; Zarzycki, J.; Steinchen, W.; Hochberg, G. K. A.; Erb, T. J.: Layered entrenchment maintains essentiality in the evolution of Form I Rubisco complexes. The EMBO Journal 44, pp. 269 - 280 (2025)

Abil, Z.; Giaveri, S.; Erb, T. J.; Rothschild, L. J.: Integrating metabolism and evolution towards the realization of synthetic life. Nature Reviews Bioengineering (2024)

Schulz-Mirbach, H.; Wichmann, P.; Satanowski, A.; Meusel, H.; Wu, T.; Nattermann, M.; Burgener, S.; Paczia, N.; Bar-Even, A.; Erb, T. J.: New-to-nature CO₂-dependent acetyl-CoA assimilation enabled by an engineered B12-dependent acyl-CoA mutase. Nature Communications 15, 10235 (2024)

He, H.; Gómez-Coronado, P. A.; Zarzycki, J.; Barthel, S.; Kahnt, J.; Claus, P.; Klein, M.; Klose, M.; de Crécy-Lagard, V.; Schindler, D. et al.; Paczia, N.; Glatter, T.; Erb, T. J.: Adaptive laboratory evolution recruits the promiscuity of succinate semialdehyde dehydrogenase to repair different metabolic deficiencies. Nature Communications 15 (1), 8898 (2024)

Barthel, S.; Brenker, L.; Diehl, C.; Bohra, N.; Giaveri, S.; Paczia, N.; Erb, T. J.: in vitro transcription-based biosensing of glycolate for prototyping of a complex enzyme cascade. Synthetic Biology, ysae013 (2024)

Schulz-Mirbach, H.; Krüsemann, J. L.; Andreadaki, T.; Nerlich, J. N.; Mavrothalassiti, E.; Boecker, S.; Schneider, P.; Weresow, M.; Abdelwahab, O.; Paczia, N. et al.; Dronsella, B.; Erb, T. J.; Bar-Even, A.; Klamt, S.; Lindner, S. N.: Engineering new-to-nature biochemical conversions by combining fermentative metabolism with respiratory modules. Nature Communications 15 (1), 6725 (2024)

Schann, K.; Bakker, J.; Boinot, M.; Kuschel, P.; He, H.; Nattermann, M.; Paczia, N.; Erb, T. J.; Bar-Even, A.; Wenk, S.: Design, construction and optimization of formaldehyde growth biosensors with broad application in biotechnology. Microbial Biotechnology 17 (7), e14527 (2024)

Kim, Y.; Lee, S. H.; Gade, P.; Nattermann, M.; Maltseva, N.; Endres, M.; Chen, J.; Wichmann, P.; Hu, Y.; Marchal, D. G. et al.; Yoshikuni, Y.; Erb, T. J.; Gonzalez, R.; Michalska, K.; Joachimiak, A.: Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family. Communications Chemistry 7 (1) (2024)

Giaveri, S.; Bohra, N.; Diehl, C.; Yang, H. Y.; Ballinger, M.; Paczia, N.; Glatter, T.; Erb, T. J.: Integrated translation and metabolism in a partially self-synthesizing biochemical network. Science 385 (6705), pp. 174 - 178 (2024)

Schada v. Borzyskowsi, L.; Lucas, H.; Kremer, K.; Barthel, S.; Pommerenke, B.; Glatter, T.; Paczia, N.; Erhard, B.; Erb, T. J.: Multiple levels of transcriptional regulation control glycolate metabolism in Paracoccus denitrificans. mBio 15 (8), e0152424 (2024)

Sendker, F. L.; Lo, Y. K.; Heimerl, T.; Bohn, S.; Persson, L. J.; Mais, C.-N.; Sadowska, W.; Paczia, N.; Nußbaum, E.; del Carmen Sánchez Olmos, M. et al.; Forchhammer, K.; Schindler, D.; Erb, T. J.; Benesch, J. L. P.; Marklund, E. G.; Bange, G.; Schuller, J. M.; Hochberg, G. K. A.: Emergence of fractal geometries in the evolution of a metabolic enzyme. Nature 628 (8009), pp. 894 - 900 (2024)

Gomez, A.; Tinzl, M.; Stoffel, G. M. M.; Westedt, H.; Grubmüller, H.; Erb, T. J.; Vöhringer-Martinez, E.; Stripp, S. T.: Infrared spectroscopy reveals metal-independent carbonic anhydrase activity in crotonyl-CoA carboxylase/reductase. Chemical Science 15 (13), pp. 4960 - 4968 (2024)

Schmidt, F. V.; Schulz, L.; Zarzycki, J.; Prinz, S.; Oehlmann, N. N.; Erb, T. J.; Rebelein, J. G.: Structural insights into the iron nitrogenase complex. Nature Structural & Molecular Biology 31 (1), pp. 150 - 158 (2024)

Gomez, A.; Erb, T. J.; Grubmüller, H.; Vöhringer-Martinez, E.: Conformational dynamics of the most efficient carboxylase contributes to efficient CO₂ fixation. Journal of Chemical Information and Modeling 63 (24), pp. 7807 - 7815 (2023)

Nattermann, M.; Wenk, S.; Pfister, P.; He, H.; Lee, S.H.; Szymanski, W.; Guntermann, N.; Zhu, F.; Nickel, L.; Wallner, C. et al.; Zarzycki, J.; Paczia, N.; Gaißert, N.; Franciò, G.; Leitner, W.; Gonzalez, R.; Erb, T. J.: Engineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo. Nature Communications 14 (1), 2682 (2023)

Marchal, D. G.; Schulz, L.; Schuster, I.; Ivanovska, J.; Paczia, N.; Prinz, S.; Zarzycki, J.; Erb, T. J.: Machine learning-supported enzyme engineering toward improved CO₂-fixation of Glycolyl-CoA carboxylase. ACS Synthetic Biology 12 (12), pp. 3521 - 3530 (2023)

Erb, T. J.: Photosynthesis 2.0: Realizing new-to-nature CO₂-fixation to overcome the limits of natural metabolism. Cold Spring Harbor Perspectives in Biology, a041669 (2023)