Publications

2024

Journal Article

Schulz-Mirbach, H.; Wichmann, P.; Satanowski, A.; Meusel, H.; Wu, T.; Nattermann, M.; Burgener, S.; Paczia, N.; Bar-Even, A.; Erb, T. J.: New-to-nature CO₂-dependent acetyl-CoA assimilation enabled by an engineered B12-dependent acyl-CoA mutase. Nature Communications 15, 10235 (2024)

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Preprint

Henriques Pereira, D. P.; Xie, X.; Beyazay, T.; Paczia, N.; Subrati, Z.; Belz, J.; Volz, K.; Tüysüz, H.; Preiner, M.: The dinucleotide structure of NAD enables specific reduction on mineral surfaces. bioRxiv: the preprint server for biology, 2024.10.11.617347 (2024)

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Journal Article

Lago-Maciel, A.; Soares, J. C.; Zarzycki, J.; Buchanan, C. J.; Reif-Trauttmansdorff, T.; Schmidt, F. V.; Lometto, S.; Paczia, N.; Schuller, J. M.; Hansen, D. F. et al.; Heller, G. T.; Prinz, S.; Hochberg, G. K. A.; Pierik, A. J.; Rebelein, J. G.: Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage. bioRxiv: the preprint server for biology, 2024.10.19.619033 (2024)

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Journal Article

He, H.; Gómez-Coronado, P. A.; Zarzycki, J.; Barthel, S.; Kahnt, J.; Claus, P.; Klein, M.; Klose, M.; de Crécy-Lagard, V.; Schindler, D. et al.; Paczia, N.; Glatter, T.; Erb, T. J.: Adaptive laboratory evolution recruits the promiscuity of succinate semialdehyde dehydrogenase to repair different metabolic deficiencies. Nature Communications 15 (1), 8898 (2024)

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Journal Article

Barthel, S.; Brenker, L.; Diehl, C.; Bohra, N.; Giaveri, S.; Paczia, N.; Erb, T. J.: in vitro transcription-based biosensing of glycolate for prototyping of a complex enzyme cascade. Synthetic Biology, ysae013 (2024)

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Journal Article

Pozhydaieva, N.; Billau, F. A.; Wolfram-Schauerte, M.; Ramírez Rojas, A. A.; Paczia, N.; Schindler, D.; Höfer, K.: Temporal epigenome modulation enables efficient bacteriophage engineering and functional analysis of phage DNA modifications. PLOS Genetics 20 (9), e1011384 (2024)

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Preprint

Orsi, E.; Schulz-Mirbach, H.; Cotton, C. A.R.; Satanowski, A.; Petri, H.; Arnold, S. L.; Grabarczyk, N.; Verbakel, R.; Jensen, K. S.; Donati, S. et al.; Paczia, N.; Glatter, T.; Küffner, A. M.; Chotel, T.; Schillmueller, F.; De Maria, A.; He, H.; Lindner, S. N.; Noor, E.; Bar-Even, A.; Erb, T. J.; Nikel, P. I.: Expanding the biotechnological scope of metabolic sensors through computation-aided designs. bioRxiv: the preprint server for biology, 2024.08.23.609350 (2024)

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Journal Article

Scarinci, G.; Ariens, J.-L.; Angelidou, G.; Schmidt, S.; Glatter, T.; Paczia, N.; Sourjik, V.: Enhanced metabolic entanglement emerges during the evolution of an interkingdom microbial community. Nature Communications 15 (1), 7238 (2024)

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Journal Article

Arias-Rojas, A.; Arifah, A. Q.; Angelidou, G.; Alshaar, B.; Schombel, U.; Forest, E.; Frahm, D.; Brinkmann, V.; Paczia, N.; Beisel, C. L. et al.; Gisch, N.; Iatsenko, I.: MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation. PLOS Pathogens 20 (8), e1012462 (2024)

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Journal Article

Schulz-Mirbach, H.; Krüsemann, J. L.; Andreadaki, T.; Nerlich, J. N.; Mavrothalassiti, E.; Boecker, S.; Schneider, P.; Weresow, M.; Abdelwahab, O.; Paczia, N. et al.; Dronsella, B.; Erb, T. J.; Bar-Even, A.; Klamt, S.; Lindner, S. N.: Engineering new-to-nature biochemical conversions by combining fermentative metabolism with respiratory modules. Nature Communications 15 (1), 6725 (2024)

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Journal Article

Schann, K.; Bakker, J.; Boinot, M.; Kuschel, P.; He, H.; Nattermann, M.; Paczia, N.; Erb, T. J.; Bar-Even, A.; Wenk, S.: Design, construction and optimization of formaldehyde growth biosensors with broad application in biotechnology. Microbial Biotechnology 17 (7), e14527 (2024)

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Journal Article

Giaveri, S.; Bohra, N.; Diehl, C.; Yang, H. Y.; Ballinger, M.; Paczia, N.; Glatter, T.; Erb, T. J.: Integrated translation and metabolism in a partially self-synthesizing biochemical network. Science 385 (6705), pp. 174 - 178 (2024)

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Journal Article

Schada v. Borzyskowsi, L.; Lucas, H.; Kremer, K.; Barthel, S.; Pommerenke, B.; Glatter, T.; Paczia, N.; Erhard, B.; Erb, T. J.: Multiple levels of transcriptional regulation control glycolate metabolism in Paracoccus denitrificans. mBio 15 (8), e0152424 (2024)

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Preprint

Küffner, A. M.; Pommerenke, B.; Kley, L.; Ng, J. Z. Y.; Prinz, S.; Tinzl-Zechner, M.; Claus, P.; Paczia, N.; Zarzycki, J.; Hochberg, G. K. A. et al.; Erb, T. J.: Bottom-up reconstruction of minimal pyrenoids provides insights into the evolution and mechanisms of carbon concentration by EPYC1 proteins. bioRxiv: the preprint server for biology, 2024.06.28.601168 (2024)

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Preprint

Pérez-López, M. I.; Lubrano, P.; Angelidou, G.; Glatter, T.; Paczia, N.; Link, H.; Sourjik, V.: The SPFH complex HflK-HflC regulates aerobic respiration in bacteria. bioRxiv: the preprint server for biology, 2024.04.21.590321 (2024)

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Journal Article

Sendker, F. L.; Lo, Y. K.; Heimerl, T.; Bohn, S.; Persson, L. J.; Mais, C.-N.; Sadowska, W.; Paczia, N.; Nußbaum, E.; del Carmen Sánchez Olmos, M. et al.; Forchhammer, K.; Schindler, D.; Erb, T. J.; Benesch, J. L. P.; Marklund, E. G.; Bange, G.; Schuller, J. M.; Hochberg, G. K. A.: Emergence of fractal geometries in the evolution of a metabolic enzyme. Nature 628 (8009), pp. 894 - 900 (2024)

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Preprint

Wolfram-Schauerte, M.; Moskalchuk, A.; Pozhydaieva, N.; Ramírez Rojas, A. A.; Schindler, D.; Kaiser, S.; Paczia, N.; Höfer, K.: T4 phage RNA is NAD-capped and alters the NAD-cap epitranscriptome of Escherichia coli during infection through a phage-encoded decapping enzyme. bioRxiv: the preprint server for biology, 2024.04.04.588121 (2024)

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Journal Article

Nomura, S.; Paczia, N.; Kahnt, J.; Shima, S.: Isolation of an H₂-dependent electron-bifurcating CO₂-reducing megacomplex with MvhB polyferredoxin from Methanothermobacter marburgensis. The FEBS Journal 291 (11), pp. 2449 - 2460 (2024)

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Journal Article

Addison, H. G.; Glatter, T.; Hochberg, G. K. A.; Rebelein, J. G.: Two distinct ferredoxins are essential for nitrogen fixation by the iron nitrogenase in Rhodobacter capsulatus. mBio 15 (3), e0331423 (2024)

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Preprint

Peters, L.; Drechsler, M.; Pees, B.; Angelidou, G.; Salzer, L.; Moors, K. A.; Paczia, N.; Schulenburg, H.; Shi, Y.-M.; Kaleta, C. et al.; Witting, M.; Bode, H. B.; Dierking, K.: Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans. bioRxiv: the preprint server for biology, 2024.02.06.579051 (2024)

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Journal Article

Schaupp, S.; Arriaza-Gallardo, F. J.; Paczia, N.; Ataka, K.; Shima, S.: Acyl and CO ligands in the [Fe]-hydrogenase cofactor scramble upon photolysis. Angewandte Chemie International Edition 63 (6), e202316478 (2024)

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DOI

2023

Journal Article

Nattermann, M.; Wenk, S.; Pfister, P.; He, H.; Lee, S.H.; Szymanski, W.; Guntermann, N.; Zhu, F.; Nickel, L.; Wallner, C. et al.; Zarzycki, J.; Paczia, N.; Gaißert, N.; Franciò, G.; Leitner, W.; Gonzalez, R.; Erb, T. J.: Engineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo. Nature Communications 14 (1), 2682 (2023)

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Journal Article

Gavriil, M.; Proietto, M.; Paczia, N.; Ginolhac, A.; Halder, R.; Valceschini, E.; Sauter, T.; Linster, C. L.; Sinkkonen, L.: 2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition. Life science alliance 7 (2), e202302333 (2023)

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DOI

Preprint

Giaveri, S.; Bohra, N.; Diehl, C.; Ballinger, M.; Paczia, N.; Glatter, T.; Erb, T. J.: An interdependent metabolic and genetic network shows emergent properties in vitro. bioRxiv: the preprint server for biology, 2023.11.26.568713 (2023)

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DOI

Journal Article

Gomes-Filho, J. V.; Breuer, R.; Morales-Filloy, H. G.; Pozhydaieva, N.; Borst, A.; Paczia, N.; Soppa, J.; Höfer, K.; Jäschke, A.; Randau, L.: Identification of NAD-RNA species and ADPR-RNA decapping in Archaea. Nature Communications 14, 7597 (2023)

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Journal Article

Marchal, D. G.; Schulz, L.; Schuster, I.; Ivanovska, J.; Paczia, N.; Prinz, S.; Zarzycki, J.; Erb, T. J.: Machine learning-supported enzyme engineering toward improved CO₂-fixation of Glycolyl-CoA carboxylase. ACS Synthetic Biology 12 (12), pp. 3521 - 3530 (2023)

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Journal Article

Lee, S. H.; Chou, A.; Nattermann, M.; Zhu, F.; Clomburg, J. M.; Paczia, N.; Erb, T. J.; Gonzalez, R.: Identification of 2-Hydroxyacyl-CoA synthases with high acyloin condensation activity for orthogonal one-carbon bioconversion. ACS Catalysis 13 (18), pp. 12007 - 12020 (2023)

MPG.PuRe

DOI

Journal Article

Kremer, K.; Meier, D.; Theis, L.; Miller, S.; Rost-Nasshan, A.; Naing, Y. T.; Zarzycki, J.; Paczia, N.; Serrania, J.; Blumenkamp, P. et al.; Goesmann, A.; Becker, A.; Thanbichler, M.; Hochberg, G. K. A.; Carter, M. S.; Erb, T. J.: Functional degeneracy in Paracoccus denitrificans Pd1222 is coordinated via RamB, which links expression of the Glyoxylate cycle to activity of the Ethylmalonyl-CoA pathway. Applied and Environmental Microbiology 89 (7), e0023823 (2023)

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Journal Article

McLean, R.; Schwander, T.; Diehl, C.; Cortina, N. S.; Paczia, N.; Zarzycki, J.; Erb, T. J.: Exploring alternative pathways for the in vitro establishment of the HOPAC cycle for synthetic CO₂ fixation. Science Advances 9 (24), eadh4299 (2023)

MPG.PuRe

DOI

Journal Article

Guo, K.; Glatter, T.; Paczia, N.; Liesack, W.: Asparagine uptake: a cellular strategy of Methylocystis to combat severe salt stress. Applied and Environmental Microbiology 89 (6), e0011323 (2023)

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DOI

Journal Article

Schada v. Borzyskowsi, L.; Schulz-Mirbach, H.; Troncoso Castellanos, M.; Severi, F.; Gomez Coronado, P. A.; Paczia, N.; Glatter, T.; Bar-Even, A.; Lindner, S. N.; Erb, T. J.: Implementation of the β-hydroxyaspartate cycle increases growth performance of Pseudomonas putida on the PET monomer ethylene glycol. Metabolic Engineering 76, pp. 97 - 109 (2023)

MPG.PuRe

DOI

Preprint

Gerlinger, P.; Angelidou, G.; Paczia, N.; Erb, T. J.: Ketosynthase engineering enhances activity and shifts specificity towards non-native extender units in type I linear polyketide synthase. bioRxiv: the preprint server for biology, 2023.02.16.528826 (2023)

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DOI

Journal Article

Diehl, C.; Gerlinger, P.; Paczia, N.; Erb, T. J.: Synthetic anaplerotic modules for the direct synthesis of complex molecules from CO₂. Nature Chemical Biology 19 (2), pp. 168 - 175 (2023)

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DOI

Journal Article

Jeckel, H.; Nosho, K.; Neuhaus, K.; Hastewell, A. D.; Skinner, D. J.; Saha, D.; Netter, N.; Paczia, N.; Dunkel, J.; Drescher, K.: Simultaneous spatiotemporal transcriptomics and microscopy of Bacillus subtilis swarm development reveal cooperation across generations. Nature Microbiology 8 (12), pp. 2378 - 2391 (2023)

MPG.PuRe

DOI

Journal Article

Kaprou, G. D.; Andar, A.; Shah, P.; Linster, C. L.; Paczia, N.: Novel design for a microfluidic-based platform for yeast replicative lifespan (RLS) analysis. Micro and Nano Engineering, 100199 (2023)

MPG.PuRe

DOI

Journal Article

Klabunde, B.; Wesener, A.; Bertrams, W.; Beinborn, I.; Paczia, N.; Surmann, K.; Blankenburg, S.; Wilhelm, J.; Serrania, J.; Knoops, K. et al.; Elsayed, E. M.; Laakmann, K.; Jung, A. L.; Kirschbaum, A.; Hammerschmidt, S.; Alshaar, B.; Gisch, N.; Abu Mraheil, M.; Becker, A.; Völker, U.; Vollmeister, E.; Benedikter, B. J.; Schmeck, B.: NAD⁺ metabolism is a key modulator of bacterial respiratory epithelial infections. Nature Communications 14 (1), 5818 (2023)

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DOI

Journal Article

Luo, S.; Adam, D.; Giaveri, S.; Barthel, S.; Cestellos-Blanco, S.; Hege, D.; Paczia, N.; Castañeda-Losada, L.; Klose, M.; Arndt, F. et al.; Heider, J.; Erb, T. J.: ATP production from electricity with a new-to-nature electrobiological module. Joule 7 (8), pp. 1745 - 1758 (2023)

MPG.PuRe

DOI

Journal Article

Luo, S.; Diehl, C.; He, H.; Bae, Y.; Klose, M.; Claus, P.; Cortina, N. S.; Fernandez, C. A.; Schulz-Mirbach, H. A. M.; McLean, R. et al.; Ramírez Rojas, A. A.; Schindler, D.; Paczia, N.; Erb, T. J.: Construction and modular implementation of the THETA cycle for synthetic CO₂ fixation. Nature Catalysis 6 (12), pp. 1228 - 1240 (2023)

MPG.PuRe

DOI

2022

Journal Article

Arriaza-Gallardo, F. J.; Schaupp, S.; Zheng, Y.-C.; Abdul-Halim, M. F.; Hui-Jie, P.; Kahnt, J.; Angelidou, G.; Paczia, N.; Hu, X.; Costa, K. et al.; Shima, S.: The function of two radical-SAM enzymes, HcgA and HcgG, in the biosynthesis of the [Fe]-hydrogenase cofactor. Angewandte Chemie, International Edition in English 61 (50), e202213239 (2022)

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DOI

Journal Article

Shi, Y.-M.; Crames, J. J.; Czech, L.; Bozhüyük, K. A. J.; Shi, Y.-N.; Hirschmann, M.; Lamberth, S.; Claus, P.; Paczia, N.; Ruckert, C. et al.; Kalinowski, J.; Bange, G.; Bode, H. B.: Genome mining enabled by biosynthetic characterization uncovers a class of benzoxazolinate-containing natural products in diverse bacteria. Angewandte Chemie, International Edition in English 61 (51), e202206106 (2022)

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Journal Article

Guo, K.; Hakobyan, A.; Glatter, T.; Paczia, N.; Liesack, W.: Methylocystis sp. strain SC2 acclimatizes to increasing NH₄⁺ levels by a precise rebalancing of enzymes and osmolyte composition. mSystems 7 (5), e0040322 (2022)

MPG.PuRe

DOI

publisher-version

Journal Article

Pandi, A.; Diehl, C.; Yazdizadeh Kharrazi, A.; Scholz, S. A.; Bobkova, E.; Faure, L.; Nattermann, M.; Adam, D.; Chapin, N.; Foroughijabbari, Y. et al.; Moritz, C.; Paczia, N.; Cortina, N. S.; Faulon, J. L.; Erb, T. J.: A versatile active learning workflow for optimization of genetic and metabolic networks. Nature Communications 13 (1), 3876 (2022)

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DOI

Journal Article

Danileviciute, E.; Zeng, N.; Capelle, C. M.; Paczia, N.; Gillespie, M. A.; Kurniawan, H.; Benzarti, M.; Merz, M. P.; Coowar, D.; Fritah, S. et al.; Weisenhorn, V.; Maria, D.; Gomez Giro, G.; Grusdat, M.; Baron, A.; Guerin, C.; Franchina, D. G.; Léonard, C.; Domingues, O.; Delhalle, S.; Wurst, W.; Turner, J. D.; Schwamborn, J. C.; Meiser, J.; Krüger, R.; Ranish, J.; Brenner, D.; Linster, C. L.; Balling, R.; Ollert, M.; Hefeng, F. Q.: PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing. Nature Metabolism 4 (5), pp. 589 - 607 (2022)

MPG.PuRe

DOI

Journal Article

Schaupp, S.; Arriaza Gallardo, F. J.; Pan, H. J.; Kahnt, J.; Angelidou, G.; Paczia, N.; Costa, K.; Hu, X.; Shima, S.: In vitro biosynthesis of the [Fe]-hydrogenase cofactor verifies the proposed biosynthetic precursors. Angewandte Chemie, International Edition in English 61 (22), e202200994 (2022)

MPG.PuRe

DOI

2021

Journal Article

Nattermann, M.; Burgener, S.; Pfister, P.; Chou, A.; Schulz, L.; Lee, S. H.; Paczia, N.; Zarzycki, J.; Gonzalez, R.; Erb, T. J.: Engineering a highly efficient carboligase for synthetic one-carbon metabolism. ACS Catalysis 11 (9), pp. 5396 - 5404 (2021)

MPG.PuRe

DOI

Journal Article

Castaneda-Losada, L.; Adam, D.; Paczia, N.; Buesen, D.; Steffler, F.; Sieber, V.; Erb, T. J.; Richter, M.; Plumere, N.: Bioelectrocatalytic cofactor regeneration coupled to CO₂ fixation in a redox-active hydrogel for stereoselective C-C bond formation. Angewandte Chemie, International Edition in English 60 (38), pp. 21056 - 21061 (2021)

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DOI

Journal Article

Sundaram, S.; Diehl, C.; Cortina, N. S.; Bamberger, J.; Paczia, N.; Erb, T. J.: A modular in vitro platform for the production of terpenes and polyketides from CO₂. Angewandte Chemie, International Edition in English 60 (30), pp. 16420 - 16425 (2021)

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Journal Article

Conrad, R.; Liu, P.; Claus, P.: Fractionation of stable carbon isotopes during acetate consumption by methanogenic and sulfidogenic microbial communities in rice paddy soils and lake sediments. Biogeosciences 18 (24), pp. 6533 - 6546 (2021)

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Journal Article

Roell, M.-S.; Schada von Borzykowski, L.; Westhoff, P.; Plett, A.; Paczia, N.; Claus, P.; Urte, S.; Erb, T. J.; Weber, A. P. M.: A synthetic C4 shuttle via the beta-hydroxyaspartate cycle in C3 plants. Proceedings of the National Academy of Sciences of the United States of America 118 (21), e2022307118 (2021)

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DOI

2020

Journal Article

Hakobyan, A.; Zhu, J.; Glatter, T.; Paczia, N.; Liesack, W.: Hydrogen utilization by Methylocystis sp. strain SC2 expands the known metabolic versatility of type IIa methanotrophs. METABOLIC ENGINEERING 61, pp. 181 - 196 (2020)

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Journal Article

Cotton, C. A. R.; Bernhardsgrütter, I.; He, H.; Burgener, S.; Schulz, L.; Paczia, N.; Dronsella, B.; Erban, A.; Toman, S.; Dempfle, M. et al.; De Maria, A.; Kopka, J.; Lindner, S. N.; Erb, T. J.; Bar-Even, A.: Underground isoleucine biosynthesis pathways in E. coli. ELIFE 9, e54207 (2020)

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DOI

Patent

Paczia, N.; Jung, P.; Shah, P.; Linster, C.; Dimaki, M.; Svendson, W.: Microfluidic system for yeast aging analysis. WO 2020/043786 A1 (2020)

MPG.PuRe

Journal Article

Burgener, S.; Cortina, N. S.; Erb, T. J.: Oxalyl-CoA Decarboxylase Enables Nucleophilic One-Carbon Extension of Aldehydes to Chiral α-Hydroxy Acids. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59 (14), pp. 5526 - 5530 (2020)

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Journal Article

Miller, T.; Beneyton, T.; Schwander, T.; Diehl, C.; Girault, M.; McLean, R.; Chotel, T.; Claus, P.; Cortina, N. S.; Baret, J.-C. et al.; Erb, T. J.: Light-powered CO₂ fixation in a chloroplast mimic with natural and synthetic parts. SI 368 (6491), pp. 649 - + (2020)

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DOI

2019

Journal Article

Schada v. Borzyskowsi, L.; Severi, F.; Krueger, K.; Hermann, L.; Gilardet, A.; Sippel, F.; Pommerenke, B.; Claus, P.; Cortina, N. S.; Glatter, T. et al.; Zauner, S.; Zarzycki, J.; Fuchs, B. M.; Bremer, E.; Maier, U. G.; Amann I, R.; Erb, T. J.: Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle. NATURE 575 (7783), pp. 500 - + (2019)

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Journal Article

Milne-Davies, B.; Helbig, C.; Wimmi, S.; Cheng, D. W. C.; Paczia, N.; Diepold, A.: Life After Secretion-Yersinia enterocolitica Rapidly Toggles Effector Secretion and Can Resume Cell Division in Response to Changing External Conditions. FRONTIERS IN MICROBIOLOGY 10, 2128 (2019)

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Journal Article

Paczia, N.; Becker-Kettern, J.; Conrotte, J.-F.; Cifuente, J. O.; Guerin, M. E.; Linster, C. L.: 3-Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo L-Serine Synthesis. SI 58 (4), pp. 259 - 275 (2019)

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Journal Article

Schymanski, E. L.; Baker, N. C.; Williams, A. J.; Singh, R. R.; Trezzi, J.-P.; Wilmes, P.; Kolber, P. L.; Kruger, R.; Paczia, N.; Linster, C. L. et al.; Balling, R.: Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges. ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS 21 (9), pp. 1426 - 1445 (2019)

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Journal Article

Van Bergen, N. J.; Guo, Y.; Rankin, J.; Paczia, N.; Becker-Kettern, J.; Kremer, L. S.; Pyle, A.; Conrotte, J.-F.; Ellaway, C.; Procopis, P. et al.; Prelog, K.; Homfray, T.; Baptista, J.; Baple, E.; Wakeling, M.; Massey, S.; Kay, D. P.; Shukla, A.; Girisha, K. M.; Lewis, L. E. S.; Santra, S.; Power, R.; Daubeney, P.; Montoya, J.; Ruiz-Pesini, E.; Kovacs-Nagy, R.; Pritsch, M.; Ahting, U.; Thorburn, D. R.; Prokisch, H.; Taylor, R. W.; Christodoulou, J.; Linster, C. L.; Ellard, S.; Hakonarson, H.: NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses. BRAIN 142, pp. 50 - 58 (2019)

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Journal Article

Veiga-da-Cunha, M.; Chevalier, N.; Stephenne, X.; Defour, J.-P.; Paczia, N.; Ferster, A.; Achouri, Y.; Dewulf, J. P.; Linster, C. L.; Bommer, G. T. et al.; Van Schaftingen, E.: Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116 (4), pp. 1241 - 1250 (2019)

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2018

Journal Article

Berhardsgrütter, I.; Vögeli, B.; Wagner, T.; Peter, D.; Cortina, N. S.; Kahnt, J.; Bange, G.; Engilberge, S.; Girard, E.; Riobe, F. et al.; Maury, O.; Shima, S.; Zarzycki, J.; Erb, T. J.: The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite. NATURE CHEMICAL BIOLOGY 14 (12), p. 1127 (2018)

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Journal Article

Vögeli, B.; Rosenthal, R.; Stoffel, G.; Wagner, T.; Kiefer, P.; Cortina, N. S.; Shima, S.; Erb, T. J.: InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis. JOURNAL OF BIOLOGICAL CHEMISTRY 293 (44), pp. 17200 - 17207 (2018)

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Journal Article

Vögeli, B.; Geyer, K.; Gerlinger, P.; Benkstein, S.; Cortina, N. S.; Erb, T. J.: Combining Promiscuous Acyl-CoA Oxidase and Enoyl-CoA Carboxylase/Reductases for Atypical Polyketide Extender Unit Biosynthesis. CELL CHEMICAL BIOLOGY 25 (7), p. 833 (2018)

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Journal Article

Becker-Kettern, J.; Paczia, N.; Conrotte, J.-F.; Zhu, C.; Fiehn, O.; Jung, P. P.; Steinmetz, L. M.; Linster, C. L.: NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells. FEBS JOURNAL 285 (18), pp. 3376 - 3401 (2018)

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Journal Article

Berger, E.; Magliaro, C.; Paczia, N.; Monzel, A. S.; Antony, P.; Linster, C. L.; Bolognin, S.; Ahluwalia, A.; Schwamborn, J. C.: Millifluidic culture improves human midbrain organoid vitality and differentiation. LAB ON A CHIP 18 (20), pp. 3172 - 3183 (2018)

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Journal Article

Jung, P. P.; Zhang, Z.; Paczia, N.; Jaeger, C.; Ignac, T.; May, P.; Linster, C. L.: Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control. NPJ AGING AND MECHANISMS OF DISEASE 4, 3 (2018)

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DOI

2017

Journal Article

Gajewski, J.; Buelens, F.; Serdjukow, S.; Janssen, M.; Cortina, N.; Grubmueler, H.; Grininger, M.: Engineering fatty acid synthases for directed polyketide production. Nature Chemical Biology 13 (4), pp. 363 - 365 (2017)

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Journal Article

Peracchi, A.; Veiga-da-Cunha, M.; Kuhara, T.; Ellens, K. W.; Paczia, N.; Stroobant, V.; Seliga, A. K.; Marlaire, S.; Jaisson, S.; Bommer, G. T. et al.; Sun, J.; Huebner, K.; Linster, C. L.; Cooper, A. J. L.; van Schaftingen, E.: Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114 (16), pp. E3233 - E3242 (2017)

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Journal Article

Zarzycki, J.; Sutter, M.; Cortina, N. S.; Erb, T. J.; Kerfeld, C. A.: In Vitro Characterization and Concerted Function of Three Core Enzymes of a Glycyl Radical Enzyme - Associated Bacterial Microcompartment. Scientific Reports 7 (1), p. 42757 (2017)

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2016

Journal Article

Peter, D.; Vögeli, B.; Cortina, N. S.; Erb, T.J.: A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters. Molecules 21 (4), 517 (2016)

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Journal Article

Becker-Kettern, J.; Paczia, N.; Conrotte, J.-F.; Kay, D. P.; Guignard, C.; Jung, P. P.; Linster, C. L.: Saccharomyces cerevisiae Forms d-2-Hydroxyglutarate and Couples Its Degradation to d-Lactate Formation via a Cytosolic Transhydrogenase. JOURNAL OF BIOLOGICAL CHEMISTRY 291 (12), pp. 6036 - 6058 (2016)

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Journal Article

Schwander, T.; Schada v. Borzyskowsi, L.; Burgener, S.; Cortina, N. S.; Erb, T. J.: A synthetic pathway for the fixation of carbon dioxide in vitro. Science 354 (6314), pp. 900 - 904 (2016)

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2014

Journal Article

Unthan, S.; Gruenberger, A.; van Ooyen, J.; Gaetgens, J.; Heinrich, J.; Paczia, N.; Wiechert, W.; Kohlheyer, D.; Noack, S.: Beyond Growth Rate 0.6: What Drives Corynebacterium glutamicum to Higher Growth Rates in Defined Medium. BIOTECHNOLOGY AND BIOENGINEERING 111 (2), pp. 359 - 371 (2014)

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2013

Patent

Paczia, N.; Schramm, C.; Noack, S.: Vorrichtung und Verfahren zur Zellseparation. 102012009088 (2013)

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Patent

von Lieres, E.; Motyll, S.; Paczia, N.: Probeentnahmevorrichtung und Verfahren zur Entnahme einer Probe aus einem Bioreaktor. 102012003113 (2013)

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Journal Article

Gruenberger, A.; van Ooyen, J.; Paczia, N.; Rohe, P.; Schiendzielorz, G.; Eggeling, L.; Wiechert, W.; Kohlheyer, D.; Noack, S.: Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments. BIOTECHNOLOGY AND BIOENGINEERING 110 (1), pp. 220 - 228 (2013)

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Book Chapter

Oldiges, M.; Noack, S.; Paczia, N.: Metabolomics in Biotechnology (Microbial Metabolomics). In: Metabolomics in Practice (2013)

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2012

Journal Article

Grünberger, A.; Paczia, N.; Probst, C.; Schendzielorz, G.; Eggeling, L.; Noack, S.; Wiechert, W.; Kohlheyer, D.: A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab Chip 12 (11), pp. 2060 - 8 (2012)

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Journal Article

Paczia, N.; Nilgen, A.; Lehmann, T.; Gaetgens, J.; Wiechert, W.; Noack, S.: Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms. MICROBIAL CELL FACTORIES 11, 122 (2012)

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Journal Article

Tillack, J.; Paczia, N.; Noh, K.; Wiechert, W.; Noack, S.: Error propagation analysis for quantitative intracellular metabolomics. Metabolites 2 (4), pp. 1012 - 30 (2012)

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