Max Planck Institute for Terrestrial Microbiology

Publications

2024

Journal Article

Effert, J.; Westphalen, M.; Calderari, A.; Shi, Y.-M.; Elamri, I.; Najah, S.; Grün, P.; Li, Y.; Gruez, A.; Weissman, K. J. et al.; Bode, H. B.: Pyrrolizwilline, a unique bacterial alkaloid assembled by a nonribosomal peptide synthetase and non-enzymatic dimerization. Angewandte Chemie International Edition, e202411258 (2024)

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Journal Article

Touray, M.; Cimen, H.; Bode, E.; Bode, H. B.; Hazir, S.: Effects of Xenorhabdus and Photorhabdus bacterial metabolites on the ovipositional activity of Aedes albopictus. Journal of Pest Science 97 (4), pp. 2203 - 2215 (2024)

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Journal Article

Su, L.; Huber, E. M.; Westphalen, M.; Gellner, J.; Bode, E.; Köbel, T.; Grün, P.; Alanjary, M. M.; Glatter, T.; Cirnski, K. et al.; Müller, R.; Schindler, D.; Groll, M.; Bode, H. B.: Isofunctional but Structurally Different Methyltransferases for Dithiolopyrrolone Diversification. Angewandte Chemie International Edition, e202410799 (2024)

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Journal Article

Präve, L.; Kuttenlochner, W.; Tabak, W. W.A.; Langer, C.; Kaiser, M.; Groll, M.; Bode, H. B.: Bioengineering of syrbactin megasynthetases for immunoproteasome inhibitor production. Chem (2024)

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Journal Article

Ulgen Gokduman, F.; Yılmaz, S.; Bode, H. B.: Enhanced production of trans-cinnamic acid in Photorhabdus luminescens with homolog expression and deletion strategies. Journal of Applied Microbiology 135 (7), lxae149 (2024)

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Journal Article

Präve, L.; Seyfert, C. E.; Bozhüyük, K. A. J.; Racine, E.; Müller, R.; Bode, H. B.: Investigation of the Odilorhabdin biosynthetic gene cluster using NRPS engineering. Angewandte Chemie International Edition 63 (33), e202406389 (2024)

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Journal Article

Ulug, D.; Touray, M.; Hazal Gulsen, S.; Cimen, H.; Hazir, C.; Bode, H. B.; Hazir, S.: A taste of a toxin paradise: Xenorhabdus and Photorhabdus bacterial secondary metabolites against Aedes aegypti larvae and eggs. Journal of Invertebrate Pathology 205, 108126 (2024)

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Journal Article

Touray, M.; Ulug, D.; Gulsen, S. H.; Cimen, H.; Hazir, C.; Bode, H. B.; Hazir, S.: Natural products from Xenorhabdus and Photorhabdus show promise as biolarvicides against Aedes albopictus. Pest Management Science 80 (9), pp. 4231 - 4242 (2024)

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Journal Article

Rill, A.; Zhao, L.; Bode, H. B.: Genetic toolbox for Photorhabdus and Xenorhabdus: pSEVA based heterologous expression systems and CRISPR/Cpf1 based genome editing for rapid natural product profiling. Microbial Cell Factories 23, 98 (2024)

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Journal Article

Bozhüyük, K. A. J.; Präve, L.; Kegler, C.; Schenk, L.; Kaiser, S.; Schelhas, C. S.; Shi, Y.-N.; Kuttenlochner, W.; Schreiber, M.; Kandler, J. et al.; Alanjary, M.; Mohiuddin, T. M.; Groll, M.; Hochberg, G. K. A.; Bode, H. B.: Evolution-inspired engineering of nonribosomal peptide synthetases. Science 383 (6689), eadg4320 (2024)

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Journal Article

Schmalhofer, M.; Vagstad, A. L.; Zhou, Q.; Bode, H. B.; Groll, M.: Polyketide trimming shapes dihydroxynaphthalene-melanin and anthraquinone pigments. Advanced Science 11 (22), e2400184 (2024)

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Journal Article

Palma, L.; Frizzo, L.; Kaiser, S.; Berry, C.; Caballero, P.; Bode, H. B.; Valle, D.; E., E.: Genome sequence analysis of native Xenorhabdus strains isolated from entomopathogenic nematodes in Argentina. Toxins 16 (2), 108 (2024)

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Preprint

Peters, L.; Drechsler, M.; Pees, B.; Angelidou, G.; Salzer, L.; Moors, K. A.; Paczia, N.; Schulenburg, H.; Shi, Y.-M.; Kaleta, C. et al.; Witting, M.; Bode, H. B.; Dierking, K.: Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans. bioRxiv: the preprint server for biology, 2024.02.06.579051 (2024)

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Preprint

Su, L.; Huber, E. M.; Westphalen, M.; Gellner, J.; Bode, E.; Köbel, T.; Grün, P.; Alanjary, M. M.; Glatter, T.; Schindler, D. et al.; Groll, M.; Bode, H. B.: Identification, structure and function of the methyltransferase involved in the biosynthesis of the dithiolopyrrolone antibiotic xenorhabdin. bioRxiv: the preprint server for biology, 2024.01.12.575338 (2024)

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2023

Preprint

Spahn, C. K.; Middlemiss, S.; Gómez-de-Mariscal, E.; Henriques, R.; Bode, H. B.; Holden, S.; Heilemann, M.: Transertion and cell geometry organize the Escherichia coli nucleoid during rapid growth. bioRxiv: the preprint server for biology, 2023.10.16.562172 (2023)

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Journal Article

Abbood, N.; Effert, J.; Bozhüyük, K. A. J.; Bode, H. B.: Guidelines for optimizing type S nonribosomal peptide synthetases. ACS Synthetic Biology 12 (8), pp. 2432 - 2443 (2023)

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Book Chapter

Abbood, N.; Präve, L.; Bozhüyük, K. A. J.; Bode, H. B.: A practical guideline to engineering nonribosomal peptide synthetases. In: Non-Ribosomal Peptide Biosynthesis and Engineering. Methods in Molecular Biology,, Vol. 2670 (Eds. Burkart, M.; Ishikawa, F.). Humana, New York, NY, New York (2023)

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Journal Article

Huber, E. M.; Kreling, L.; Heinrich, A. K.; Dunnebacke, M.; Pothig, A.; Bode, H. B.; Groll, M.: A set of closely related methyltransferases for site-specific tailoring of anthraquinone pigments. Structure 31 (5), 573-583.e5. (2023)

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Journal Article

Awori, R. M.; Waturu, C. N.; Pidot, S. J.; Amugune, N. O.; Bode, H. B.: Draft genomes, phylogenomic reconstruction and comparative genome analysis of three Xenorhabdus strains isolated from soil dwelling nematodes in Kenya. Access Microbiology 5 (5), acmi000531.v4 (2023)

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Journal Article

Bode, E.; Assmann, D.; Happel, P.; Meyer, E.; Münch, K.; Roessel, N.; Bode, H. B.: easyPACId, a simple method for induced production, isolation, identification, and testing of natural products from Proteobacteria. Bio-protocol 13 (13), e4709 (2023)

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Journal Article

Cai, X.; Zhao, L.; Bode, H. B.: Engineering of specific single-module nonribosomal peptide synthetases of the RXP type for the production of defined peptides. ACS Synthetic Biology 12 (1), pp. 203 - 212 (2023)

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Journal Article

Jin, G.; Hrithik, M. T. H.; Lee, D.-H.; Kim, I.-H.; Jung, J.-S.; Bode, H. B.; Kim, Y.: Manipulation of GameXPeptide synthetase gene expression by a promoter exchange alters the virulence of an entomopathogenic bacterium, Photorhabdus temperata temperata, by modulating insect immune responses. Frontiers in Microbiology 14, 1271764 (2023)

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Journal Article

Meesil, W.; Muangpat, P.; Sitthisak, S.; Rattanarojpong, T.; Chantratita, N.; Machado, R. A. R.; Shi, Y.-M.; Bode, H. B.; Vitta, A.; Thanwisai, A.: Genome mining reveals novel biosynthetic gene clusters in entomopathogenic bacteria. Scientific Reports 13, 20764 (2023)

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Journal Article

Pandi, A.; Adam, D.; Zare, A.; Trinh, V. T.; Schaefer, S. L.; Burt, M.; Klabunde, B.; Bobkova, E.; Kushwaha, M.; Foroughijabbari, Y. et al.; Braun, P.; Spahn, C. K.; Preußer, C.; Pogge von Strandmann, E.; Bode, H. B.; von Buttlar, H.; Bertrams, W.; Jung, A. L.; Abendroth, F.; Schmeck, B.; Hummer, G.; Vázquez, O.; Erb, T. J.: Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. Nature Communications 14 (1), 7197 (2023)

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2022

Journal Article

Kavakli, S.; Grammbitter, G. L. C.; Bode, H. B.: Biosynthesis of the multifunctional isopropylstilbene in Photorhabdus laumondii involves cross-talk between specialized and primary metabolism. Tetrahedron 128, 133116 (2022)

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Journal Article

Shi, Y.-M.; Crames, J. J.; Czech, L.; Bozhüyük, K. A. J.; Shi, Y.-N.; Hirschmann, M.; Lamberth, S.; Claus, P.; Paczia, N.; Ruckert, C. et al.; Kalinowski, J.; Bange, G.; Bode, H. B.: Genome mining enabled by biosynthetic characterization uncovers a class of benzoxazolinate-containing natural products in diverse bacteria. Angewandte Chemie, International Edition in English 61 (51), e202206106 (2022)

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Journal Article

Muangpat, P.; Meesil, W.; Ngoenkam, J.; Teethaisong, Y.; Thummeepak, R.; Sitthisak, S.; Tandhavanant, S.; Chantratita, N.; Bode, H. B.; Vitta, A. et al.; Thanwisai, A.: Genome analysis of secondary metabolitebiosynthetic gene clusters of Photorhabdus akhurstii subsp. akhurstii and its antibacterial activity against antibiotic-resistant bacteria. PLOS ONE 17 (9), e0274956 (2022)

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Journal Article

Shi, Y.-M.; Hirschmann, M.; Shi, Y.-N.; Bode, H. B.: Cleavage off-loading and post-assembly-line conversions yield products with unusual termini during biosynthesis. ACS Chemical Biology 17 (8), pp. 2221 - 2228 (2022)

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Journal Article

Ahmed, S.; Tafim Hossain Hrithik, M.; Chandra Roy, M.; Bode, H. B.; Kim, Y.: Phurealipids, produced by the entomopathogenic bacteria, Photorhabdus, mimic juvenile hormone to suppress insect immunity and immature development. Journal of Invertebrate Pathology 193, 107799 (2022)

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Journal Article

Gulsen, S. H.; Tileklioglu, E.; Bode, E.; Cimen, H.; Ertabaklar, H.; Ulug, D.; Ertug, S.; Wenski, S. L.; Touray, M.; Hazir, C. et al.; Bilecenoglu, D. K.; Yildiz, I.; Bode, H. B.; Hazir, S.: Antiprotozoal activity of different Xenorhabdus and Photorhabdus bacterial secondary metabolites and identification of bioactive compounds using the easyPACId approach. Scientific Reports 12 (1), 10779 (2022)

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Journal Article

Abbood, N.; Vo, T. D.; Watzel, J.; Bozhueyuek, K. A. J.; Bode, H. B.: Type S non-ribosomal peptide synthetases for the rapid generation of tailormade peptide libraries. Chemistry – A European Journal 28 (26), e202103963 (2022)

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Journal Article

Shi, Y.-M.; Hirschmann, M.; Shi, Y.-N.; Ahmed, S.; Abebew, D.; Tobias, N. J.; Grun, P.; Crames, J. J.; Pöschel, L.; Kuttenlochner, W. et al.; Richter, C.; Herrmann, J.; Muller, R.; Thanwisai, A.; Pidot, S. J.; Stinear, T. P.; Groll, M.; Kim, Y.; Bode, H. B.: Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria. Nature Chemistry 14, pp. 701 - 712 (2022)

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Journal Article

Sarawi, S.; Shi, Y.-N.; Lotz-Winter, H.; Reschke, K.; Bode, H. B.; Piepenbring, M.: Occurrence and chemotaxonomical analysis of amatoxins in Lepiota spp. (Agaricales). Phytochemistry 195, 113069 (2022)

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Journal Article

Abebew, D.; Sayedain, F.; Bode, E.; Bode, H. B.: Uncovering nematicidal natural products from Xenorhabdus bacteria. Journal of Agricultural and Food Chemistry 70 (2), pp. 498 - 506 (2022)

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Journal Article

Gerke, J.; Köhler, A. M.; Wennrich, J.-P.; Große, V.; Shao, L.; Heinrich, A. K.; Bode, H. B.; Chen, W.; Surup, F.; Braus, G. H.: Biosynthesis of antibacterial iron-chelating tropolones in Aspergillus nidulans as response to glycopeptide-producing Streptomycetes. Frontiers in Fungal Biology 2, 777474 (2022)

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Magazine Article

Abbood, N.; Bozhüyük, K. A. J.; Bode, H. B.: Synthetische Zipper für die Biosynthese neuer Naturstoffderivate. (2022)

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Journal Article

Zolfaghariyan, S.; Shakeri, A.; Asili, J.; Tarighi, S.; Grün, P.; Shi, Y.-M.; Bode, H. B.; Karimi, J.: Cyclic depsipeptides and linear peptides with cytotoxic and antiphytopathogenic activities from symbiotic bacteria of Xenorhabdus (Enterobacteriales: Morganellaceae) genus. Annals of the Entomological Society of America 116 (2), pp. 114 - 124 (2022)

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2021

Preprint

Kranz, J.; Wenski, S. L.; Dichter, A. A.; Bode, H. B.; Bozhüyük, K. A. J.: Influence of condensation domains on activity and specificity of adenylation domains. bioRxiv: the preprint server for biology, 2021.08.23.457306 (2021)

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Journal Article

Miethke, M.; Pieroni, M.; Weber, T.; Bronstrup, M.; Hammann, P.; Halby, L.; Arimondo, P. B.; Glaser, P.; Aigle, B.; Bode, H. B. et al.; Moreira, R.; Li, Y.; Luzhetskyy, A.; Medema, M. H.; Pernodet, J.-L.; Stadler, M.; Tormo, J. R.; Genilloud, O.; Truman, A. W.; Weissman, K. J.; Takano, E.; Sabatini, S.; Stegmann, E.; Brotz-Oesterhelt, H.; Wohlleben, W.; Seemann, M.; Empting, M.; Hirsch, A. K. H.; Loretz, B.; Lehr, C.-M.; Titz, A.; Herrmann, J.; Jaeger, T.; Alt, S.; Hesterkamp, T.; Winterhalter, M.; Schiefer, A.; Pfarr, K.; Hoerauf, A.; Graz, H.; Graz, M.; Lindvall, M.; Ramurthy, S.; Karlen, A.; van Dongen, M.; Petkovic, H.; Keller, A.; Peyrane, F.; Donadio, S.; Fraisse, L.; Piddock, L. J. V.; Gilbert, I. H.; Moser, H. E.; Muller, R.: Towards the sustainable discovery and development of new antibiotics. Nature Reviews Chemistry 5 (10), pp. 726 - 749 (2021)

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Journal Article

Erkoc, P.; Schmitt, M.; Ingelfinger, R.; Bischoff-Kont, I.; Kopp, L.; Bode, H. B.; Schiffmann, S.; Fuerst, R.: Xenocoumacin 2 reduces protein biosynthesis and inhibits inflammatory and angiogenesis-related processes in endothelial cells. Biomedicine & Pharmacotherapy 140, 111765 (2021)

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Journal Article

Cimen, H.; Touray, M.; Gulsen, S. H.; Erincik, O.; Wenski, S. L.; Bode, H. B.; Shapiro-Ilan, D.; Hazir, S.: Antifungal activity of different Xenorhabdus and Photorhabdus species against various fungal phytopathogens and identification of the antifungal compounds from X. szentirmaii. Applied Microbiology and Biotechnology 105 (13), pp. 5517 - 5528 (2021)

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Journal Article

Behsaz, B.; Bode, E.; Gurevich, A.; Shi, Y.-N.; Grundmann, F.; Acharya, D.; Caraballo-Rodriguez, A. M.; Bouslimani, A.; Panitchpakdi, M.; Linck, A. et al.; Guan, C.; Oh, J.; Dorrestein, P. C.; Bode, H. B.; Pevzner, P. A.; Mohimani, H.: Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery (vol 12, 3225, 2021). Nature Communications 12 (1), 4318 (2021)

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Journal Article

Singh, G.; Calchera, A.; Schulz, M.; Drechsler, M.; Bode, H. B.; Schmitt, I.; Dal Grande, F.: Climate-specific biosynthetic gene clusters in populations of a lichen-forming fungus. Environmental Microbiology 23 (8), pp. 4260 - 4275 (2021)

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Journal Article

Behsaz, B.; Bode, E.; Gurevich, A.; Shi, Y.-N.; Grundmann, F.; Acharya, D.; Caraballo-Rodriguez, A. M.; Bouslimani, A.; Panitchpakdi, M.; Linck, A. et al.; Guan, C.; Oh, J.; Dorrestein, P. C.; Bode, H. B.; Pevzner, P. A.; Mohimani, H.: Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery. Nature Communications 12 (1), 3225 (2021)

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Journal Article

Incedayi, G.; Cimen, H.; Ulug, D.; Touray, M.; Bode, E.; Bode, H. B.; Yaylagul, E. O.; Hazir, S.; Cakmak, I.: Relative potency of a novel acaricidal compound from Xenorhabdus, a bacterial genus mutualistically associated with entomopathogenic nematodes. Scientific Reports 11 (1), 11253 (2021)

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Journal Article

Bozhüyük, K. A. J.; Watzel, J.; Abbood, N.; Bode, H. B.: Synthetic zippers as an enabling tool for engineering of non-ribosomal peptide synthetases**. Angewandte Chemie International Edition 60 (32), pp. 17531 - 17538 (2021)

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Journal Article

Zhao, L.; Le Chapelain, C.; Brachmann, A. O.; Kaiser, M.; Groll, M.; Bode, H. B.: Activation, structure, biosynthesis and bioactivity of glidobactin-like proteasome inhibitors from Photorhabdus laumondii. ChemBioChem 22 (9), pp. 1582 - 1588 (2021)

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Journal Article

Watzel, J.; Duchardt-Ferner, E.; Sarawi, S.; Bode, H. B.; Wohnert, J.: Cooperation between a T domain and a minimal C-terminal docking domain to enable specific assembly in a multiprotein NRPS. Angewandte Chemie International Edition 60 (25), pp. 13685 - 14194 (2021)

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Journal Article

Brachmann, A. O.; Probst, S. I.; Ruethi, J.; Dudko, D.; Bode, H. B.; Piel, J.: A desaturase-like enzyme catalyzes oxazole formation in Pseudomonas indolyloxazole alkaloids. Angewandte Chemie International Edition 60 (16), pp. 8781 - 8785 (2021)

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Journal Article

Watzel, J.; Sarawi, S.; Duchardt-Ferner, E.; Bode, H. B.; Woehnert, J.: NMR resonance assignments for a docking domain pair with an attached thiolation domain from the PAX peptide-producing NRPS from Xenorhabdus cabanillasii. Biomolecular NMR Assignments 15 (1), pp. 229 - 234 (2021)

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Journal Article

Schorn, M. A.; Verhoeven, S.; Ridder, L.; Huber, F.; Acharya, D. D.; Aksenov, A. A.; Aleti, G.; Moghaddam, J. A.; Aron, A. T.; Aziz, S. et al.; Bauermeister, A.; Bauman, K. D.; Baunach, M.; Beemelmanns, C.; Beman, J. M.; Berlanga-Clavero, M. V.; Blacutt, A. A.; Bode, H. B.; Boullie, A.; Brejnrod, A.; Bugni, T. S.; Calteau, A.; Cao, L.; Carrion, V. J.; Castelo-Branco, R.; Chanana, S.; Chase, A. B.; Chevrette, M. G.; Costa-Lotufo, L. V.; Crawford, J. M.; Currie, C. R.; Cuypers, B.; Dang, T.; de Rond, T.; Demko, A. M.; Dittmann, E.; Du, C.; Drozd, C.; Dujardin, J. C.; Dutton, R. J.; Edlund, A.; Fewer, D. P.; Garg, N.; Gauglitz, J. M.; Gentry, E. C.; Gerwick, L.; Glukhov, E.; Gross, H.; Gugger, M.; Guillen Matus, D. G.; Helfrich, E. J. N.; Hempel, B. F.; Hur, J. S.; Iorio, M.; Jensen, P. R.; Kang, K. B.; Kaysser, L.; Kelleher, N. L.; Kim, C. S.; Kim, K. H.; Koester, I.; Konig, G. M.; Leao, T.; Lee, S. R.; Lee, Y. Y.; Li, X.; Little, J. C.; Maloney, K. N.; Mannle, D.; Martin, H. C.; McAvoy, A. C.; Metcalf, W. W.; Mohimani, H.; Molina-Santiago, C.; Moore, B. S.; Mullowney, M. W.; Muskat, M.; Nothias, L. F.; O'Neill, E. C.; Parkinson, E. I.; Petras, D.; Piel, J.; Pierce, E. C.; Pires, K.; Reher, R.; Romero, D.; Roper, M. C.; Rust, M.; Saad, H.; Saenz, C.; Sanchez, L. M.; Sorensen, S. J.; Sosio, M.; Sussmuth, R. D.; Sweeney, D.; Tahlan, K.; Thomson, R. J.; Tobias, N. J.; Trindade-Silva, A. E.; van Wezel, G. P.; Wang, M.; Weldon, K. C.; Zhang, F.; Ziemert, N.; Duncan, K. R.; Crusemann, M.; Rogers, S.; Dorrestein, P. C.; Medema, M. H.; van der Hooft, J. J. J.: A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology 17 (4), pp. 363 - 368 (2021)

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Journal Article

Vo, T. D.; Spahn, C.; Heilemann, M.; Bode, H. B.: Microbial cationic peptides as a natural defense mechanism against insect antimicrobial peptides. ACS Chemical Biology 16 (3), pp. 447 - 451 (2021)

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Journal Article

Sayedain, F. S.; Ahmadzadeh, M.; Fattah-Hosseini, S.; Bode, H. B.: Soil application of entomopathogenic nematodes suppresses the root-knot nematode Meloidogyne javanicain cucumber. Journal of Plant Diseases and Protection 128 (1), pp. 215 - 223 (2021)

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Journal Article

Wenski, S. L.; Berghaus, N.; Keller, N.; Bode, H. B.: Structure and biosynthesis of deoxy-polyamine in Xenorhabdus bovienii. Journal of Industrial Microbiology & Biotechnology 48 (3-4), kuab006 (2021)

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Journal Article

Machado, R. A. R.; Muller, A.; Ghazal, S. M.; Thanwisai, A.; Pages, S.; Bode, H. B.; Hussein, M. A.; Khalil, K. M.; Tisa, L. S.: Photorhabdus heterorhabditis subsp. aluminescens subsp. nov., Photorhabdus heterorhabditis subsp. heterorhabditis subsp. nov., Photorhabdus australis subsp. thailandensis subsp. nov., Photorhabdus australis subsp. australis subsp. nov., and Photorhabdus aegyptia sp. nov. isolated from Heterorhabditis entomopathogenic nematodes. International Journal of Systematic and Evolutionary Microbiology 71 (1), 004610 (2021)

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Journal Article

Reyes-Fernandez, E. Z.; Shi, Y.-M.; Gruen, P.; Bode, H. B.; Boelker, M.: An unconventional melanin biosynthesis pathway in Ustilago maydis. Applied and Environmental Microbiology 87 (3), e01510-20 (2021)

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Journal Article

Maher, A. M. D.; Asaiyah, M.; Quinn, S.; Burke, R.; Wolff, H.; Bode, H. B.; Griffin, C. T.: Competition and co-existence of two Photorhabdus symbionts with a nematode host. Microbial Ecology 81 (1), pp. 223 - 239 (2021)

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Journal Article

Murray, A. E.; Freudenstein, J.; Gribaldo, S.; Hatzenpichler, R.; Hugenholtz, P.; Kampfer, P.; Konstantinidis, K. T.; Lane, C. E.; Papke, R. T.; Parks, D. H. et al.; Rossello-Mora, R.; Stott, M. B.; Sutcliffe, I. C.; Thrash, J. C.; Venter, S. N.; Whitman, W. B.; Acinas, S. G.; Amann, R. I.; Anantharaman, K.; Armengaud, J.; Baker, B. J.; Barco, R. A.; Bode, H. B.; Boyd, E. S.; Brady, C. L.; Carini, P.; Chain, P. S. G.; Colman, D. R.; DeAngelis, K. M.; de los Rios, M. A.; de los Santos, P.; Dunlap, C. A.; Eisen, J. A.; Emerson, D.; Ettema, T. J. G.; Eveillard, D.; Girguis, P. R.; Hentschel, U.; Hollibaugh, J. T.; Hug, L. A.; Inskeep, W. P.; Ivanova, E. P.; Klenk, H.-P.; Li, W.-J.; Lloyd, K. G.; Loffler, F. E.; Makhalanyane, T. P.; Moser, D. P.; Nunoura, T.; Palmer, M.; Parro, V.; Pedros-Alio, C.; Probst, A. J.; Smits, T. H. M.; Steen, A. D.; Steenkamp, E. T.; Spang, A.; Stewart, F. J.; Tiedje, J. M.; Vandamme, P.; Wagner, M.; Wang, F.-P.; Yarza, P.; Hedlund, B. P.; Reysenbach, A.-L.: Roadmap for naming uncultivated Archaea and Bacteria (vol 5, pg 987, 2020). Nature Microbiology 6 (1), p. 136 - 136 (2021)

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2020

Preprint

Grammbitter, G. L. C.; Shi, Y.-M.; Shi, Y.-N.; Vemulapalli, S. P. B.; Richter, C.; Schwalbe, H.; Alanjary, M.; Schüffler, A.; Witt, M.; Griesinger, C. et al.; Bode, H. B.: The chemical structure of widespread microbial aryl polyene lipids. bioRxiv: the preprint server for biology, 2020.12.19.423268 (2020)

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Journal Article

Neubacher, N.; Tobias, N. J.; Huber, M.; Cai, X.; Glatter, T.; Pidot, S. J.; Stinear, T. P.; Lutticke, A. L.; Papenfort, K.; Bode, H. B.: Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA. Nat Microbiol 5 (12), pp. 1481 - 1489 (2020)

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Journal Article

Braeuer, A.; Zhou, Q.; Grammbitter, G. L. C.; Schmalhofer, M.; Ruehl, M.; Kaila I, V. R.; Bode, H. B.; Groll, M.: Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis. NATURE CHEMISTRY 12 (8) (2020)

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Journal Article

Kegler, C.; Bode, H. B.: Artificial Splitting of a Non-Ribosomal Peptide Synthetase by Inserting Natural Docking Domains. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59 (32), pp. 13463 - 13467 (2020)

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Journal Article

Machado, R. A. R.; Thoenen, L.; Arce, C. C. M.; Theepan, V.; Prada, F.; Wuethrich, D.; Robert, C. A. M.; Vogiatzaki, E.; Shi, Y.-M.; Schaeren, O. P. et al.; Notter, M.; Bruggmann, R.; Hapfelmeier, S.; Bode, H. B.; Erb, M.: Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm (Feb, 10.1038/s41587-020-0419-1, 2020). NATURE BIOTECHNOLOGY 38 (5), p. 649 - 649 (2020)

MPG.PuRe

Journal Article

Machado, R. A. R.; Thonen, L.; Arce, C. C. M.; Theepan, V.; Prada, F.; Wuthrich, D.; Robert, C. A. M.; Vogiatzaki, E.; Shi, Y.-M.; Schaeren, O. P. et al.; Notter, M.; Bruggmann, R.; Hapfelmeier, S.; Bode, H. B.; Erb, M.: Engineering bacterial symbionts of nematodes improves biocontrol potential of the western corn rootworm. NATURE BIOTECHNOLOGY 38 (5) (2020)

MPG.PuRe

Journal Article

Murray, A. E.; Freudenstein, J.; Gribaldo, S.; Hatzenpichler, R.; Hugenholtz, P.; Kaempfer, P.; Konstantinidis, K. T.; Lane, C. E.; Papke, R. T.; Parks, D. H. et al.; Rossello-Mora, R.; Stott, M. B.; Sutcliffe, I. C.; Thrash, J. C.; Venter, S. N.; Whitman, W. B.; Acinas, S. G.; Amann I, R.; Anantharaman, K.; Armengaud, J.; Baker, B. J.; Barco, R. A.; Bode, H. B.; Boyd, E. S.; Brady, C. L.; Carini, P.; Chain, P. S. G.; Colman, D. R.; DeAngelis, K. M.; de los Rios, M. A.; Estrada-de los Santos, P.; Dunlap, C. A.; Eisen, J. A.; Emerson, D.; Ettema, T. J. G.; Eveillard, D.; Girguis, P. R.; Hentschel, U.; Hollibaugh, J. T.; Hug, L. A.; Inskeep, W. P.; Ivanova, E. P.; Klenk, H.-P.; Li, W.-J.; Lloyd, K. G.; Lffler, F. E.; Makhalanyane, T. P.; Moser, D. P.; Nunoura, T.; Palmer, M.; Parro, V.; Pedros-Alio, C.; Probst, A. J.; Smits, T. H. M.; Steen, A. D.; Steenkamp, E. T.; Spang, A.; Stewart, F. J.; Tiedje, J. M.; Vandamme, P.; Wagner, M.; Wang, F.-P.; Hedlund, B. P.; Reysenbach, A.-L.: Roadmap for naming uncultivated Archaea and Bacteria. NATURE MICROBIOLOGY 5 (8), pp. 987 - 994 (2020)

MPG.PuRe

Journal Article

Siebels, I.; Nowak, S.; Heil, C. S.; Tufar, P.; Cortina, N. S.; Bode, H. B.; Grininger, M.: Cell-Free Synthesis of Natural Compounds from Genomic DNA of Biosynthetic Gene Clusters. ACS SYNTHETIC BIOLOGY 9 (9), pp. 2418 - 2426 (2020)

MPG.PuRe

Journal Article

Tietze, A.; Shi, Y.-N.; Kronenwerth, M.; Bode, H. B.: Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains. CHEMBIOCHEM 21 (19), pp. 2750 - 2754 (2020)

MPG.PuRe

Journal Article

Tobias, N. J.; Brehm, J.; Kresovic, D.; Brameyer, S.; Bode, H. B.; Heermann, R.: New Vocabulary for Bacterial Communication. CHEMBIOCHEM 21 (6), pp. 759 - 768 (2020)

MPG.PuRe

Journal Article

Watzel, J.; Hacker, C.; Duchardt-Ferner, E.; Bode, H. B.; Woehnert, J.: A New Docking Domain Type in the Peptide-Antimicrobial-Xenorhabdus Peptide Producing Nonribosomal Peptide Synthetase from Xenorhabdus bovienii. ACS CHEMICAL BIOLOGY 15 (4), pp. 982 - 989 (2020)

MPG.PuRe

Journal Article

Wenskil, S. L.; Cimen, H.; Berghaus, N.; Fuchs, S. W.; Hazir, S.; Bode, H. B.: Fabclavine diversity in Xenorhabdus bacteria. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 16, pp. 956 - 965 (2020)

MPG.PuRe

Journal Article

Zhao, L.; Vo, T. D.; Kaiser, M.; Bode, H. B.: Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity. CHEMBIOCHEM 21 (9), pp. 1288 - 1292 (2020)

MPG.PuRe

2019

Journal Article

Reinheimer, C.; Buttner, D.; Proschak, E.; Bode, H. B.; Kempf, V. A. J.; Wichelhaus, T. A.: Anti-tubercular activity of a natural stilbene and its synthetic derivatives. GMS Infect Dis 6, p. Doc01 (2019)

MPG.PuRe

Journal Article

Armaleo, D.; Mueller, O.; Lutzoni, F.; Andresson, O. S.; Blanc, G.; Bode, H. B.; Collart, F. R.; Dal Grande, F.; Dietrich, F.; Grigoriev, I. V. et al.; Joneson, S.; Kuo, A.; Larsen, P. E.; Logsdon Jr., J. M.; Lopez, D.; Martin, F.; May, S. P.; McDonald, T. R.; Merchant, S. S.; Miao, V.; Morin, E.; Oono, R.; Pellegrini, M.; Rubinstein, N.; Sanchez-Puerta, M. V.; Savelkoul, E.; Schmitt, I.; Slot, J. C.; Soanes, D.; Szovenyi, P.; Talbot, N. J.; Veneault-Fourrey, C.; Xavier, B. B.: The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata. BMC GENOMICS 20, 605 (2019)

MPG.PuRe

Journal Article

Berry, D.; Mace, W.; Grage, K.; Wesche, F.; Gore, S.; Schardl, C. L.; Young, C. A.; Dijkwel, P. P.; Leuchtmann, A.; Bode, H. B. et al.; Scott, B.: Efficient nonenzymatic cyclization and domain shuffling drive pyrrolopyrazine diversity from truncated variants of a fungal NRPS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116 (51), pp. 25614 - 25623 (2019)

MPG.PuRe

Journal Article

Bode, E.; Heinrich, A. K.; Hirschmann, M.; Abebew, D.; Shi, Y.-N.; Tien Vo, D.; Wesche, F.; Shi, Y.-M.; Gruen, P.; Simonyi, S. et al.; Keller, N.; Engel, Y.; Wenski, S.; Bennet, R.; Beyer, S.; Bischoff, I.; Buaya, A.; Brandt, S.; Cakmak, I.; Cimen, H.; Eckstein, S.; Frank, D.; Fuerst, R.; Gand, M.; Geisslinger, G.; Hazir, S.; Henke, M.; Heermann, R.; Lecaudey, V.; Schaefer, W.; Schiffmann, S.; Schueffler, A.; Schwenk, R.; Skaljac, M.; Thines, E.; Thines, M.; Ulshoefer, T.; Vilcinskas, A.; Wichelhaus, T. A.; Bode, H. B.: Promoter Activation in Delta hfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 (52), pp. 18957 - 18963 (2019)

MPG.PuRe

Journal Article

Bozhueyuek, K. A. J.; Linck, A.; Tietze, A.; Kranz, J.; Wesche, F.; Nowak, S.; Fleischhacker, F.; Shi, Y.-N.; Gruen, P.; Bode, H. B.: Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains. NATURE CHEMISTRY 11 (7), pp. 653 - 661 (2019)

MPG.PuRe

Journal Article

Cai, X.; Zhao, L.; Bode, H. B.: Reprogramming Promiscuous Nonribosomal Peptide Synthetases for Production of Specific Peptides. ORGANIC LETTERS 21 (7), pp. 2116 - 2120 (2019)

MPG.PuRe

Journal Article

Calchera, A.; Dal Grande, F.; Bode, H. B.; Schmitt, I.: Biosynthetic Gene Content of the "Perfume Lichens' Evernia prunastri and Pseudevernia furfuracea. MOLECULES 24 (1), 203 (2019)

MPG.PuRe

Journal Article

Drummond, L.; Kschowak, M. J.; Breitenbach, J.; Wolff, H.; Shi, Y.-M.; Schrader, J.; Bode, H. B.; Sandmann, G.; Buchhaupt, M.: Expanding the Isoprenoid Building Block Repertoire with an IPP Methyltransferase from Streptomyces monomycini. ACS SYNTHETIC BIOLOGY 8 (6), pp. 1303 - 1313 (2019)

MPG.PuRe

Journal Article

Grammbitter, G. L. C.; Schmalhofer, M.; Karimi, K.; Shi, Y.-M.; Schoener, T. A.; Tobias, N. J.; Morgner, N.; Groll, M.; Bode, H. B.: An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 141 (42), pp. 16615 - 16623 (2019)

MPG.PuRe

Journal Article

Hasan, A.; Yeom, H.-S.; Ryu, J.; Bode, H. B.; Kim, Y.: Phenylethylamides derived from bacterial secondary metabolites specifically inhibit an insect serotonin receptor. SCIENTIFIC REPORTS 9, 20358 (2019)

MPG.PuRe

Journal Article

Kissoyan, K. A. B.; Drechsler, M.; Stange, E.-L.; Zimmermann, J.; Kaleta, C.; Bode, H. B.; Dierking, K.: Natural C-elegans Microbiota Protects against Infection via Production of a Cyclic Lipopeptide of the Viscosin Group. CURRENT BIOLOGY 29 (6), pp. 1030 - + (2019)

MPG.PuRe

Journal Article

Ozkan, H. D.; Cimen, H.; Ulug, D.; Wenski, S.; Ozer, S. Y.; Telli, M.; Aydin, N.; Bode, H. B.; Hazir, S.: Nematode-Associated Bacteria: Production of Antimicrobial Agent as a Presumptive Nominee for Curing Endodontic Infections Caused by Enterococcus faecalis. FRONTIERS IN MICROBIOLOGY 10, 2672 (2019)

MPG.PuRe

Journal Article

Schmidt, R.; Ulanova, D.; Wick, L. Y.; Bode, H. B.; Garbeva, P.: Microbe-driven chemical ecology: past, present and future. ISME JOURNAL 13 (11), pp. 2656 - 2663 (2019)

MPG.PuRe

Journal Article

Shi, Y.-M.; Brachmann, A. O.; Westphalen, M. A.; Neubacher, N.; Tobias, N. J.; Bode, H. B.: Dual phenazine gene clusters enable diversification during biosynthesis. NATURE CHEMICAL BIOLOGY 15 (4), pp. 331 - + (2019)

MPG.PuRe

Journal Article

Shi, Y.-N.; Pusch, S.; Shi, Y.-M.; Richter, C.; Macia-Vicente, J. G.; Schwalbe, H.; Kaiser, M.; Opatz, T.; Bode, H. B.: (+/-)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp. JOURNAL OF ORGANIC CHEMISTRY 84 (17), pp. 11203 - 11209 (2019)

MPG.PuRe

Journal Article

Sonner, J. K.; Keil, M.; Falk-Paulsen, M.; Mishra, N.; Rehman, A.; Kramer, M.; Deumelandt, K.; Roewe, J.; Sanghvi, K.; Wolf, L. et al.; von Landenberg, A.; Wolff, H.; Bharti, R.; Oezen, I.; Lanz V, T.; Wanke, F.; Tang, Y.; Brandao, I.; Mohapatra, S. R.; Epping, L.; Grill, A.; Roeth, R.; Niesler, B.; Meuth, S. G.; Opitz, C. A.; Okun, J. G.; Reinhardt, C.; Kurschus, F. C.; Wick, W.; Bode, H. B.; Rosenstiel, P.; Platten, M.: Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology. NATURE COMMUNICATIONS 10, 4877 (2019)

MPG.PuRe

Journal Article

Tobias, N. J.; Bode, H. B.: Heterogeneity in Bacterial Specialized Metabolism. SI 431 (23), pp. 4589 - 4598 (2019)

MPG.PuRe

Journal Article

Tobias, N. J.; Parra-Rojas, C.; Shi, Y.-N.; Shi, Y.-M.; Simonyi, S.; Thanwisai, A.; Vitta, A.; Chantratita, N.; Hernandez-Vargas, E. A.; Bode, H. B.: Cyclo(tetrahydroxybutyrate) production is sufficient to distinguish between Xenorhabdus and Photorhabdus isolates in Thailand. ENVIRONMENTAL MICROBIOLOGY 21 (8), pp. 2921 - 2932 (2019)

MPG.PuRe

Journal Article

Wang, G.; Zhao, Z.; Ke, J.; Engel, Y.; Shi, Y.-M.; Robinson, D.; Bingol, K.; Zhang, Z.; Bowen, B.; Louie, K. et al.; Wang, B.; Evans, R.; Miyamoto, Y.; Cheng, K.; Kosina, S.; De Raad, M.; Silva, L.; Luhrs, A.; Lubbe, A.; Hoyt, D. W.; Francavilla, C.; Otani, H.; Deutsch, S.; Washton, N. M.; Rubin, E. M.; Mouncey, N. J.; Visel, A.; Northen, T.; Cheng, J.-F.; Bode, H. B.; Yoshikuni, Y.: CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria. NATURE MICROBIOLOGY 4 (12), pp. 2498 - 2510 (2019)

MPG.PuRe

Journal Article

Wenski, S. L.; Kolbert, D.; Grammbitter, G. L. C.; Bode, H. B.: Fabclavine biosynthesis in X. szentirmaii: shortened derivatives and characterization of the thioester reductase FclG and the condensation domain-like protein FclL. SI 46 (3-4), pp. 565 - 572 (2019)

MPG.PuRe

Journal Article

Wesche, F.; Adihou, H.; Wichelhaus, T. A.; Bode, H. B.: Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 15, pp. 535 - 541 (2019)

MPG.PuRe

Journal Article

Zhao, L.; Awori, R. M.; Kaiser, M.; Gross, J.; Opatz, T.; Bode, H. B.: Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1. JOURNAL OF NATURAL PRODUCTS 82 (12), pp. 3499 - 3503 (2019)

MPG.PuRe

Journal Article

Zhao, L.; Bode, H. B.: Production of a photohexapeptide library from entomopathogenic Photorhabdus asymbiotica PB68.1. ORGANIC & BIOMOLECULAR CHEMISTRY 17 (34), pp. 7858 - 7862 (2019)

MPG.PuRe

Journal Article

Zhou, Q.; Braeuer, A.; Adihou, H.; Schmalhofer, M.; Saura, P.; Grammbitter, G. L. C.; Kaila, V. R. I.; Groll, M.; Bode, H. B.: Molecular mechanism of polyketide shortening in anthraquinone biosynthesis of Photorhabdus luminescens. CHEMICAL SCIENCE 10 (25), pp. 6341 - 6349 (2019)

MPG.PuRe

2018

Journal Article

Bozhueyuek, K. A. J.; Fleischhacker, F.; Linck, A.; Wesche, F.; Tietze, A.; Niesert, C.-P.; Bode, H. B.: De novo design and engineering of non-ribosomal peptide synthetases. NATURE CHEMISTRY 10 (3), pp. 275 - 281 (2018)

MPG.PuRe

Report

Bozhüyük, K. A. J.; Bode, H. B.: Innovative Anti-Infectives – Synthetic Biology for the Production of Complex Peptides. (2018)

MPG.PuRe

Report

Bozhüyük, K. A. J.; Bode, H. B.: Wirkstoff-Forschung: Herstellung maßgeschneiderter komplexer Peptide. (2018)

MPG.PuRe

Journal Article

Hacker, C.; Cai, X.; Kegler, C.; Zhao, L.; Weickhmann, A. K.; Wurm, J. P.; Bode, H. B.; Woehnert, J.: Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS. NATURE COMMUNICATIONS 9, 4366 (2018)

MPG.PuRe