Bacterial Epitranscriptomics
Dr. Katharina Höfer
Research area
RNA`s simple chemical composition, being generally built from only four different nucleotides, stands in stark contrast to its highly complex functionality. To date, more than 160 chemical modifications are known that alter the function or stability of RNA molecules. Focusing primarily on the model organism Escherichia coli, the Höfer lab studies the epitranscriptomic mechanisms of gene regulation based on NAD-capped RNAs in bacteria. To identify novel and important connections between redox biology, gene expression and regulation they are combining cell biological, biochemical, structural, chemical and bioinformatic approaches.
Selected recent publications
Hinrichs, R.; Pozhydaieva, N.; Höfer, K.; Graumann, P.L. (2022) Y-Complex Proteins Show RNA-Dependent Binding Events at the Cell Membrane and Distinct Single-Molecule Dynamics. Cells, 11, 933. DOI
Höfer, K.*+, Schauerte, M.*,Grawenhoff, J., Wulf, A., Welp, L. M., Billau, F. A., Urlaub, H., Jäschke, A.+. (2021)
Viral ADP-ribosyltransferases attach RNA chains to host proteins bioRxiv 2021.06.04.446905; DOI (+ corresponding author, *shared first author)
Schauerte, M., Pozhydaieva, N., Höfer, K. (2021)
Shaping the Bacterial Epitranscriptome—5′-Terminal and Internal RNA Modifications. Adv. Biology 2021, 2100834. DOI
Kolmar T, Büllmann SM, Sarter C, Höfer K, Jäschke A (2021).
Development of High‐Performance Pyrimidine Nucleoside and Oligonucleotide Diarylethene Photoswitches, Angewandte Chemie. DOI
Möhler M, Höfer K, Jäschke A (2020).
Synthesis of 5′-Thiamine-Capped RNA. Molecules, 25(23), 5492 DOI
Abele, F*; Höfer, K*; Bernhard, P; Grawenhoff, J; Seidel, M; Krause, A; Kopf, S; Schröter, M; Jäschke, A.(2020)
A Novel NAD-RNA Decapping Pathway Discovered by Synthetic Light-Up NAD-RNAs. Biomolecules 10, 513 DOI